Search Results - jiliang+gao

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CXCR4 Reduction Leads to Enhancement of Engraftment of Hematopoietic Stem Cells

Methods of enhancing engraftment of donor hematopoietic stem cells (HSCs) by reducing expression or activity of CXCR4 in HSCs is described. HSC are the only cells in the bone marrow that are both pluripotent and long lived. Bone marrow transplantation (BMT) using HSC is an increasingly common medical therapy for severe hematologic cancers and primary...

Published: 10/28/2024 | Inventor(s): Philip Murphy, David Mcdermott, Marie Siwiki, Harry Malech, Qian Liu, Jiliang Gao

Keywords(s): Cell, COPY, CXCR4, Durably, ENGRAFTMENT, Enhanced, hematopoietic, ONE, SILENCING, Stem, VCXXXX, VPXXXX, WJXXXX, XEXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease

Mice Genetically Deficient in the Chemoattractant Receptor FPR (formyl peptide receptor)

The present research tool is a knockout mouse model (FPR-/-) that lacks the high affinity N-formylpeptide receptor (FPR), created by targeted gene disruption. N-formylpeptides derive from bacterial and mitochondrial proteins, and bind to specific receptors on mammalian phagocytes. Since binding induces chemotaxis and activation of phagocytes in vitro,...

Published: 10/28/2024 | Inventor(s): Jiliang Gao, Philip Murphy

Keywords(s): BAXXXX, CHEMOATTRACTANT, DDXXXX, DEFICIENT, DEXXXX, DXXXXX, Formyl, FPR, GENETICALLY, knockout mice, Mice, MXXXXX, Peptide, RECEPTOR, RM, WIXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, Application > Consumer Products, ResearchProducts > Animal Models

Mouse Lacking the Chemokine Receptor CX3CR1

This mouse has been generated by targeted gene disruption. The mouse provides a model to investigate the function of the chemokine receptor CX3CR1, which is a proinflammatory receptor for the leukocyte chemoattractant CX3CL1 (aka fractalkine). As an example, the mouse is in use in the study of atherosclerosis. Further, the mouse may serve as a model...

Published: 10/28/2024 | Inventor(s): Philip Murphy, Jiliang Gao

Keywords(s): CA1AXX, CA1XXX, CAXXXX, CXXXXX, RXXXXX

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Oncology

Mouse CCR1 cDNA

A plasmid encodes mouse C-C motif chemokine receptor 1 (CCR1). CCR1 plays an important role in host protection from inflammatory response, and susceptibility to virus and parasite.

Published: 10/28/2024 | Inventor(s): Jiliang Gao, Philip Murphy

Keywords(s): CCR1, cDNA, Encoding, Listed LPM Ano as of 4/15/2015, Mouse, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, RM, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials