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Novel Method and Kit Using Monoclonal Antibodies for More Sensitive Detection of Dengue Virus

Following primary dengue virus (DENV) infection, non-structural protein 1 (NS1), a dengue-specific glycoprotein, is present in blood and is easily detected by various assays. However, for any infection thereafter (secondary infection), bioavailability of the glycoprotein greatly reduces sensitivity of DENV detection. Since secondary DENV infection is...

Published: 7/25/2024 | Inventor(s): Tesfaye Taye, Betty Poole-Smith, Elizabeth Hunsperger

Keywords(s): 1NS1, ACUTE, antibodies, Anti-dengue, DA4XXX, DDXXXX, DENV, Diagnosis, Infection, monoclonal, Mouse, NCEZID/DVBD, Non-structural, Protein, virus, VLXXXX, WBXXXX, WIXXXX, XAXXXX, XCXXXX, XDXXXX, XHXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, ResearchProducts > Research Equipment, TherapeuticArea > Infectious Disease, ResearchProducts > Antibodies, Application > Medical Devices, Application > Diagnostics, Application > Non-Medical Devices, Application > Research Materials

Use of Vitronectin as a Biomarker for the Detection of Dengue Hemorrhagic Fever

Dengue hemorrhagic fever (DHF) is a severe, potentially deadly infection spread by mosquitos. CDC scientists have identified vitronectin as an important biomarker of DHF. They have shown vitronectin is significantly reduced in DHF and severe dengue infections when compared to dengue non-hemorrhagic fever patients. Presently, DHF is established by assessing...

Published: 7/25/2024 | Inventor(s): Momar Ndao, Kay Tomashek, Betty Poole-Smith, Elizabeth Hunsperger

Keywords(s): assay, Biomarker, DA4BXX, DA4XXX, DAXXXX, DENGUE, Detection, diagnostic, DIFFERENTIATION, DXXXXX, FEVER, HEMORRHAGIC, HOST, UB1XXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, TherapeuticArea > Infectious Disease