Search Results - raul+sakoda

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Methods of Producing Thymic Emigrants from Induced Pluripotent Stem Cells

Abstract: Hematopoietic and pluripotent stem cells can be differentiated into T cells with potential clinical utility. Current approaches for in vitro T cell production rely on Notch signaling and artificial mimicry of thymic selection. However, these approaches result in unconventional or phenotypically aberrant T cells; which may lead to unpredictable...

Published: 4/8/2024 | Inventor(s): Raul Sakoda, Nicholas Klemen, Nicholas Restifo

Keywords(s): DIFFERENTIATION, Induced Pluripotent Stem Cells, IPSCS, RESEARCH MATERIAL, Restifo, T Cells, Thymic Environment, Tool

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Efficient Methods to Prepare Hematopoietic Progenitor Cells in vitro for Therapeutic Use

Abstract: Hematopoietic progenitor cells (HPC) are multi-potent hematopoietic lineage cells that can differentiate into any type of blood cell, including but not limited to erythrocytes, T cells, B cells, and natural killer cells. As such, they have high therapeutic potential in the fields of regenerative medicine and cancer immunotherapy, especially...

Published: 4/8/2024 | Inventor(s): Raul Sakoda, Nicholas Restifo, Meghan Good, Naritaka Tamaoki

Keywords(s): 3D Culture, BIOREACTOR, Hematopoietic Progenitor Cells, hiPSC, hMSC, HPC, Human Mesenchymal Stem Cells, Immunotherapy, Induced Pluripotent Stem Cells, iPSC, Vizcardo

Category(s): TherapeuticArea > Immunology, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing

High-Throughput Generation of Induced Pluripotent Stem Cells Carrying Antigen-Specific T Cell Receptors from Tumor Infiltrated Lymphocytes

Abstract: One form of adoptive T cell therapy (ACT) consists of harvesting tumor infiltrating lymphocytes (TIL), screening and isolating TIL which display tumor antigen-specific T-cell receptors (TCR), expanding the isolated T cells in vitro, and reinfusing them into the patient for treatment. While highly active in the treatment of certain cancers...

Published: 4/8/2024 | Inventor(s): Raul Sakoda, S M Rafiqul Islam, Naritaka Tamaoki, Takuya Maeda, Nicholas Restifo

Keywords(s): act, adoptive cell therapy, ANTIGEN-SPECIFIC, Cancer Targets, Immunotherapy, Induced Pluripotent Stem Cells, iPSC, Restifo, Rosenberg, T Cell Receptors, TCR, TIL, Tumor Infiltrated Lymphocytes

Category(s): TherapeuticArea > Oncology, TherapeuticArea > Immunology, Application > Therapeutics, Collaboration Sought > Licensing

In vitro Generation of an Autologous Thymic Organoid from Human Pluripotent Stem Cells

Abstract: The thymus is an integral part of the adaptive immune system as it generates T cells. Its function diminishes rapidly as the body ages, leading to a compromise of the immune system in the elderly. Reconstitution of adaptive immunity through mass production of different T cell types is therefore a therapeutic need in immunocompromised populations....

Published: 4/8/2024 | Inventor(s): Raul Sakoda, Nicholas Restifo

Keywords(s): Aging, IMMUNOCOMPROMISED, Immunotherapy, Natural Killer T Cells, NKT, Organogenesis, Organoid, Pluripotent Stem Cells, T Cells, THYMUS, Vizcardo

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Collaboration Sought > Licensing