Search Results - organoid

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In vitro Generation of an Autologous Thymic Organoid from Human Pluripotent Stem Cells

Abstract: The thymus is an integral part of the adaptive immune system as it generates T cells. Its function diminishes rapidly as the body ages, leading to a compromise of the immune system in the elderly. Reconstitution of adaptive immunity through mass production of different T cell types is therefore a therapeutic need in immunocompromised populations....

Published: 4/8/2024 | Inventor(s): Raul Sakoda, Nicholas Restifo

Keywords(s): Aging, IMMUNOCOMPROMISED, Immunotherapy, Natural Killer T Cells, NKT, Organogenesis, Organoid, Pluripotent Stem Cells, T Cells, THYMUS, Vizcardo

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Collaboration Sought > Licensing

Method for Assembling Decellularized Tissue Extracellular Matrix in 3D Tumor Spheroids

Abstract: Cell culture investigations using spheroids and organoid models have had a major impact on biomedical advancement as alternative sources for costly, in vivo animal testing. However, these 3-D cell constructs are limited in that they do not integrate extracellular components within the structure important for more reliable and accurate biological...

Published: 12/17/2024 | Inventor(s): Matthew Wolf, Michael Buckenmeyer, Elizabeth Brooks

Keywords(s): ECM, extracellular matrix, Organoid, Scaffold, Spheroid, Wolf

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology