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Efficient Methods to Prepare Hematopoietic Progenitor Cells in vitro for Therapeutic Use

Abstract: Hematopoietic progenitor cells (HPC) are multi-potent hematopoietic lineage cells that can differentiate into any type of blood cell, including but not limited to erythrocytes, T cells, B cells, and natural killer cells. As such, they have high therapeutic potential in the fields of regenerative medicine and cancer immunotherapy, especially...

Published: 4/8/2024 | Inventor(s): Raul Sakoda, Nicholas Restifo, Meghan Good, Naritaka Tamaoki

Keywords(s): 3D Culture, BIOREACTOR, Hematopoietic Progenitor Cells, hiPSC, hMSC, HPC, Human Mesenchymal Stem Cells, Immunotherapy, Induced Pluripotent Stem Cells, iPSC, Vizcardo

Category(s): TherapeuticArea > Immunology, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing

High-Throughput Generation of Induced Pluripotent Stem Cells Carrying Antigen-Specific T Cell Receptors from Tumor Infiltrated Lymphocytes

Abstract: One form of adoptive T cell therapy (ACT) consists of harvesting tumor infiltrating lymphocytes (TIL), screening and isolating TIL which display tumor antigen-specific T-cell receptors (TCR), expanding the isolated T cells in vitro, and reinfusing them into the patient for treatment. While highly active in the treatment of certain cancers...

Published: 4/8/2024 | Inventor(s): Raul Sakoda, S M Rafiqul Islam, Naritaka Tamaoki, Takuya Maeda, Nicholas Restifo

Keywords(s): act, adoptive cell therapy, ANTIGEN-SPECIFIC, Cancer Targets, Immunotherapy, Induced Pluripotent Stem Cells, iPSC, Restifo, Rosenberg, T Cell Receptors, TCR, TIL, Tumor Infiltrated Lymphocytes

Category(s): TherapeuticArea > Oncology, TherapeuticArea > Immunology, Application > Therapeutics, Collaboration Sought > Licensing

Rapid and Robust Differentiation of Human iPSCs into Motor Neurons

This technology includes a system that allows for robust differentiation of human-induced pluripotent stem cells (iPSC) into motor neurons within a time frame of 7 to 10 days. To differentiate the iPSC, a stable transgene is inserted into the CLYBL safe harbor locus in the human genome using TALENs. The transgene allows for doxycycline-inducible expression...

Published: 7/25/2024 | Inventor(s): Michael Ward, Christopher Grunseich

Keywords(s): DIFFERENTIATION, Factor-Medeated, Human, iPSC, MOTOR, Neurons, transcription, VPXXXX, WIXXXX, XEXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, Application > Research Materials

Induced Pluripotent Stem Cells Generated Using Lentivirus-based Reprogramming

Five human induced pluripotent stem cells (iPSC) lines are generated using lentivirus-based reprogramming technology. These lines are pluripotent, meaning they have the potential to differentiate into all cells in the body, and theoretically can proliferate/self-renew indefinitely. The iPSC lines are: NC1 (derived from female's fibroblasts), NC2 (derived...

Published: 7/25/2024 | Inventor(s): Guibin Chen, Manfred Boehm

Keywords(s): Cell, FIVE, GCXXXX, Generation, GXXXXX, Human, IDXXXX, INDUCED, iPSC, IXXXXX, Lines, Pluripotent, RXXXXX, Stem

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Therapeutics, Application > Research Materials