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Improved Culture Medium for Stem Cell Maintenance and Differentiation

A novel low protein culture medium with defined chemical components that allows pluripotent stem cell maintenance and differentiation is disclosed. The present technology also provides for production of high quality cardiac cells from human embryonic and induced pluripotent stem cells in chemically defined medium conditions. Human pluripotent stem...

Published: 7/25/2024 | Inventor(s): Yongshun Lin, Guokai Chen

Keywords(s): AC5XXX, ACXXXX, ADDITIVES, AXXXXX, Cell, Chemically, CM-dextran, CULTURE, DEFINED, DIFFERENTIATION, GLYCOGEN, HEPARIN, Human, IMPROVING, Lipid, Maintenance, Medium, Pluripotent, RXXXXX, Stem, Trehalose

Category(s): Collaboration Sought > Collaboration, Application > Research Materials

Platform Technology Using Ubiquitin to Improve the Delivery and Efficacy of Cytosolic Targeted Toxins

Targeted toxins (TT) are hybrid protein drugs consisting of ligands that bind to the surface of cancer cells and deliver polypeptide toxins that kill malignant cells by inactivating cytosolic protein synthesis and inducing cell death. A major challenge in the construction of targeted toxins is reducing the nonspecific binding of the toxin moiety to...

Published: 8/15/2024 | Inventor(s): Stephen Leppla, Shihui Liu, Thomas Morley, Christopher Bachran

Keywords(s): ACTING, CBXXXX, CXXXXX, Cytosolic, EFFICACY, FUSIONS, IMPROVING, Targeted, TOXINS, Ubiquitin

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology