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Platform Technology Using Ubiquitin to Improve the Delivery and Efficacy of Cytosolic Targeted Toxins

Targeted toxins (TT) are hybrid protein drugs consisting of ligands that bind to the surface of cancer cells and deliver polypeptide toxins that kill malignant cells by inactivating cytosolic protein synthesis and inducing cell death. A major challenge in the construction of targeted toxins is reducing the nonspecific binding of the toxin moiety to...

Published: 8/15/2024 | Inventor(s): Stephen Leppla, Shihui Liu, Thomas Morley, Christopher Bachran

Keywords(s): ACTING, CBXXXX, CXXXXX, Cytosolic, EFFICACY, FUSIONS, IMPROVING, Targeted, TOXINS, Ubiquitin

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology