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Near-IR Light-Cleavable Antibody Conjugates and Conjugate Precursors

Abstract: This invention describes a general way to trigger the release of a bioactive small molecule from a targeting antibody. The key “trigger” is a fluorescent linker that is chemically disassembled upon irradiation with light in the near-IR range (~800 nm). This linker technology is a dramatic step forward for the field. The molecules can be tracked...

Published: 4/8/2024 | Inventor(s): Martin Schnermann, Alexander Gorka, Hisataka Kobayashi, Roger Nani

Keywords(s): ADC, Antibody-drug Conjugate, Chemical linkers, Fluorescent linker, PDT, personalized medicine, Photodynamic therapy, Targeted drug release, Targeted therapy

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics