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Selective 12-Human Lipoxygenase Inhibitors for the Treatment of Diabetes and Clotting
This invention discloses small molecule inhibitors of human 12-lipoxygenase (12-hLO). 12-lipoxygenase expression, activation, and lipid metabolites have been implicated in type 1 and type 2 diabetes, cardiovascular disease, hypertension, Alzheimer’s, and Parkinson’s disease. The development of 12-hLO inhibitors may be a potent intracellular approach...
Published: 10/28/2024
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Inventor(s):
Jerry Nadler
,
Michael Holinstat
,
Anton Simeonov
,
Ajit Jadhav
,
Theodore Holman
,
David Maloney
Keywords(s):
12-human
,
Cardiovascular
,
CAUSED
,
Clot
,
DIABETES
,
Discovery
,
Disease
,
Formation
,
IA1AXX
,
IA1XXX
,
IAXXXX
,
Inhibitors
,
IXXXXX
,
LIPOXYGENASE
,
Platelet-mediated
,
Prevention
,
SELECTIVE
,
treatment
Category(s):
Collaboration Sought > Licensing
,
Application > Research Materials
,
TherapeuticArea > Cardiology
,
Application > Therapeutics
,
Application > Diagnostics
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