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Virus Replicon Particles as Rift Valley Fever Vaccines

Rift Valley fever (RVF) virus primarily infects animals but also has the capacity to infect humans. The disease causes abortion and death among RVF-infected livestock, resulting in substantial economic loss to people living in many parts of Africa and Arabian Peninsula. Currently, there is no commercial vaccine for RVF. CDC scientists have developed...

Published: 7/25/2024 | Inventor(s): Cesar Albarino, Brian Bird, Stuart Nichol, Kimberly Dodd

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, DC5BXX, DC5XXX, DCXXXX, DXXXXX, FEVER, OID-NCEZID-DHCPP, PARTICLES, Replicon, RIFT, THEREOF, Valley, virus, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WFXXXX, WIXXXX, WJXXXX, WMXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, ResearchProducts > Antibodies, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, Application > Occupational Safety and Health, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, Application > Vaccines, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Dental

Novel Rift Valley Fever Virus Vaccines

This invention relates to recombinant Rift Valley fever (RVF) viruses containing deletions in one or more virulence genes. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent RVF infection in livestock and humans. The recombinant RVF viruses grow to high titers, provide protective...

Published: 7/25/2024 | Inventor(s): Cesar Albarino, Stuart Nichol, Thomas Ksiazek, Brian Bird

Keywords(s): Biodefense, bioterrorism, Bioterrorist, CDC Docket Import, CDC Docket Import CDC Prosecuting, DB4BXX, DB4XXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DEVELOPING, DXXXXX, FEVER, Livestock, Method, methodology, Methods, Mosquito, Mosquitoes, OID-NCEZID-DHCPP, recombinant, Recombinant DNA, RIFT, rift valley, rift valley fever, rift valley fever virus, RVF, travel, traveler, travelers, tropical, Vaccine, Valley, VBXXXX, Vector, Vector-based, Vector-borne, Vector-borne diseases, VETERINARY, VETERINARY vaccine, viral, virus, Viruses, VLXXXX, VOXXXX, WAXXXX, WIXXXX, WMXXXX, XEXXXX, XHXXXX, YBXXXX, YCXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, Application > Consumer Products, Application > Diagnostics, ResearchProducts > Research Equipment, Application > Research Materials