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Reduced Virulence Crimean-Congo Hemorrhagic Fever Virus for Vaccine Development

This invention relates to a genetically modified hemorrhagic fever virus that can be used as an effective live vaccine agent. Hemorrhagic fever evades the human immune response using the viral ovarian tumor domain (vOTU) protease, which inhibits critical host-immunity functions. The present genetically modified virus has a vOTU protease with decreased...

Published: 7/25/2024 | Inventor(s): Scott Pegan, MIchelle Deaton, Stuart Nichol, Eric Bergeron

Keywords(s): ABLATION, Activities, Crimean-Congo, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DeiSGylating, Deubiqutinating, Domain, DXXXXX, FEVER, HEMORRHAGIC, OVARIAN, Protease's, SIMULTANEOUS, tumor, Vaccine, virus

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials