Search Results - tumor+suppressor

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Cell Line for Production of Recombinant Human Tissue Inhibitor of Metalloproteinase-2

Abstract: Studies have shown that Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) suppresses tumor growth and tumor-associated angiogenesis. Currently, the main obstacle in using TIMP-2 as a biologic therapeutic has been the inability to produce sufficient quantities of the protein for testing and development. NCI Radiation Oncology Branch (ROB)...

Published: 5/23/2024 | Inventor(s): William Stetler-Stevens, Beiyang Wei

Keywords(s): CANCER, Cerebrovascular Infarct, HEK-293F Cell Line, Ischemic and Neurodegenerative Diseases, Myocardial Infarct, Stetler-Stevenson, TIMP-2, Tissue Inhibitor of Metalloproteinases 2, tumor suppressor

Category(s): TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Research Materials, Collaboration Sought > Licensing

Prostatic Adenocarcinoma Cells Expressing or Lacking the Tumor Suppressor Gene PTEN

PTEN is a tumor suppressor gene that is frequently deleted or mutated in a variety of human cancers, including prostate, breast, endometrial, lung, and ovarian cancers. In prostate cancer cells, PTEN deletion is the most common event observed. The loss of PTEN is thought to play and important role in tumor cell proliferation and metastasis due to...

Published: 4/8/2024 | Inventor(s): Michael Quon, Derek Leroith

Keywords(s): ADENOCARCINOMA, BREAST CANCER, CA1XXX, CANCER, CAXXXX, CCXXXX, Cells, CHARACTERIZATION, Chromosome 7, monosomy, CXXXXX, Deletion 7, endometrial, Expressing, Gene, IGF1R, lung cancer, MEN 1, OVARIAN CANCER, PROSTATE CANCER, PTEN, tumor suppressor, Zollinger-Ellison syndrome

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials