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Personalized Body Weight Management System Using Monitoring Devices and Mathematical Models of Metabolism
Attempts to manage body weight are often unsuccessful or only temporary. This is, in part, due to antiquated dieting methods that attempt to address calorie consumption while ignoring metabolic and physical changes. Personalized and more comprehensive methods to track and manage body weight may be more effective. To that end, scientists at the National...
Published: 7/25/2024   |   Inventor(s): Kevin Hall
Keywords(s): ADXXXX, AXXXXX, Body, CONTROL, FEEDBACK, IA6XXX, IAXXXX, IXXXXX, Model-based, Personalized, System, Weight
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials
Rapid and Sensitive Detection of Nucleic Acid Sequence Variations
The ability to easily detect small mutations in nucleic acids, such as single base substitutions, can provide a powerful tool for use in cancer detection, perinatal screens for inherited diseases, and analysis of genetic polymorphisms such as genetic mapping or for identification purposes. Current approaches make use of the mismatch that occurs between...
Published: 4/8/2024   |   Inventor(s): Kenji Adzuma, Kiyoshi Mizuuchi, Katsuhiko Yanagihara
Keywords(s): (4)r syndrome, AC6XXX, ACXXXX, AXXXXX, C syndrome, CA1AXX, CA1XXX, CAXXXX, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, CXXXXX, Cystic fibrosis, Detection, DNA, Fragile X syndrome, G syndrome, Genetic, Huntington disease, Huntington disease; Huntington's disease, Hypertelorism with esophageal abnormality and hypospadias, IA6XXX, IAXXXX, Insertion, IXXXXX, Method, Mismatch-Targeted, Muscular dystrophy, Mutations, N syndrome, R(6) syndrome, R(7) syndrome, Syndrome X, Transposon, W syndrome, W syndrome; Syndrome W
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Oncology
Novel Methods for Using Biomarkers to Monitor Glucose Levels and Screen for Diabetes Risk
A primary goal of diabetes therapy is to improve control of blood glucose levels (known as glycemic control) in patients. Prospective studies of both Type 1 and Type 2 diabetes indicate that careful glycemic control significantly reduces the risk of microvascular, neurological, and cardiovascular complications of diabetes. The current method of monitoring...
Published: 7/25/2024   |   Inventor(s): Perry Blackshear
Keywords(s): IA6XXX, IAXXXX, IXXXXX
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics
Pain Control by the Selective Local Ablation of Nociceptive Neurons
The vanilloid receptor (VR) is a cation channel predominantly expressed on the peripheral processes and perikarya of nociceptive primary afferent neurons. Previous studies have shown that activation of the peripheral receptors by agonists such as capsaicin from hot peppers, or the much more potent resiniferatoxin, produces acute pain sensation which...
Published: 7/25/2024   |   Inventor(s): Michael Iadarola, Zoltan Olah
Keywords(s): IA6XXX, IAXXXX, IXXXXX, NB2XXX, NBXXXX, NXXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Neurology, Application > Therapeutics, Application > Research Materials, Application > Diagnostics
TMC1, a Deafness-Related Gene
Hearing loss is a common communication disorder affecting nearly 1 in 1,000 children in the United States alone, and nearly 50% of adults by the age of eighty. Hearing loss can be caused by environmental and disease-related factors; however, hearing loss due to genetic factors accounts for approximately 50% of cases. The NIH announces the isolation...
Published: 7/25/2024   |   Inventor(s): Andrew Griffith
Keywords(s): Hereditary deafness, IA6XXX, IAXXXX, IB6XXX, IBXXXX, IXXXXX, UAXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Rare / Neglected Diseases, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Reproductive Health
Materials And Methods For Detection And Treatment Of Insulin Dependent Diabetes
Insulin-dependent diabetes mellitus (IDDM) affects close to one million people in the United States. It is an autoimmune disease in which the immune system produces antibodies that attack the body's own insulin-manufacturing cells in the pancreas. Patients require daily injections of insulin to regulate blood sugar levels. The invention identified two...
Published: 7/25/2024   |   Inventor(s): Abner Notkins
Keywords(s): IA6XXX, IAXXXX, IB6XXX, IBXXXX, IXXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Reproductive Health, Application > Vaccines
Genes For Niemann-Pick Type C Disease
Niemann-Pick disease is a class of inherited lipid storage diseases. Niemann-Pick Type C disease is an autosomal recessive neurovisceral lipid storage disorder which leads to systemic and neurological abnormalities including ataxia, seizures, and loss of speech. Patients with the disease typically die as children. The biochemical hallmark of Niemann-Pick...
Published: 4/8/2024   |   Inventor(s): Danilo Tagle, Melissa Ashlock, Peter Pentchev, Jill Morris, Stacie Loftus, Jessie Gu, Eugene Carstea
Keywords(s): C, Disease, Duke DNA Project, GAXXXX, GENES, GXXXXX, IA6XXX, IAXXXX, IXXXXX, NA2BXX, NA2XXX, NAXXXX, NIEMANN-PICK, Niemann-Pick disease, NXXXXX, Pick disease of the brain, Pick's disease, TYPE, UA1XXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Neurology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases
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