Search Results - nb2xxx

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Novel Dopamine D2 Receptor Antagonists and Methods of Their Use

Investigators at the NIH have identified a series of novel, small molecule antagonists of the dopamine D2 receptor. Among the dopamine receptor (DAR) subtypes, D2 DAR is arguably one of the most validated drug targets in neurology and psychiatry. For instance, all receptor-based anti-Parkinsonian drugs work via stimulating the D2 DAR, whereas all FDA...

Published: 7/25/2024 | Inventor(s): Juan Marugan, Jingbo Xiao, Marc Ferrer-Alegre, Noel Southall, R Benjamin Free, David Sibley

Keywords(s): Agents, ANTAGONISTS, ANTIPSYCHOTIC, D2, Dopamine, Human, NB2BXX, NB2XXX, Potential, RECEPTOR, SELECTIVE, VEXXXX, VNXXXX, WIXXXX, WKXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Psychiatry/Mental Health, TherapeuticArea > Neurology, Application > Research Materials, Application > Therapeutics

Treatment of Alcoholism by Inhibition of the Neuropeptide Y Receptor

Aversive or anticraving medications are currently used to supplement behavioral treatment of alcohol dependence. However, there is a need for developing more effective medications than those available. Neuropeptide Y (NPY) is a neurotransmitter known for increasing appetite and possibly having a role in alcohol preference and dependence. This is likely...

Published: 4/8/2024 | Inventor(s): Markus Heilig

Keywords(s): ALCOHOLISM, Inhibitors, NB2FXX, NB2XXX, NBXXXX, neuropeptide, NXXXXX, RECEPTOR, treatment, Y2

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Neurology

Pain Control by the Selective Local Ablation of Nociceptive Neurons

The vanilloid receptor (VR) is a cation channel predominantly expressed on the peripheral processes and perikarya of nociceptive primary afferent neurons. Previous studies have shown that activation of the peripheral receptors by agonists such as capsaicin from hot peppers, or the much more potent resiniferatoxin, produces acute pain sensation which...

Published: 7/25/2024 | Inventor(s): Michael Iadarola, Zoltan Olah

Keywords(s): IA6XXX, IAXXXX, IXXXXX, NB2XXX, NBXXXX, NXXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Neurology, Application > Therapeutics, Application > Research Materials, Application > Diagnostics