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MDCK-based Reporter System for Detection of Influenza Viruses, Antiviral Drug Screening, and Analysis of Neutralizing Antibodies

CDC researchers have developed a Madin-Darby Canine Kidney (MDCK) reporter cell line that is exceptionally permissive for influenza virus replication and provides a highly specific, sensitive approach for the simultaneous detection and isolation of influenza viruses. Simplified antibody neutralization assays and high-throughput antiviral drug screening...

Published: 7/25/2024 | Inventor(s): Zhu Guo, Sandra Perez DeBretschneider, Ruben Donis

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, CELL-BASED, Detection, INFLUENZA, MDCK, REPORTER, System, VBXXXX, Viruses, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WFXXXX, WHXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, XAXXXX, XCXXXX, XEXXXX, XHXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Immunology, ResearchProducts > Antibodies, Application > Research Materials, Application > Occupational Safety and Health, Application > Vaccines, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Consumer Products

MDCK Cells with Enhanced Characteristics for Vaccine and Virus Production

This technology relates to compositions and methods for improving the growth characteristics of cells engineered to produce live viruses such as the Influenza virus. Featured is a method that uses the gene candidate, siat7e, or its expressed or inhibited products in Madin Darby Canine Kidney (MDCK) cells. The gene expression modulates anchorage-dependence...

Published: 7/25/2024 | Inventor(s): Chia Chu, Joseph Shiloach

Keywords(s): Anchorage-independent, CAPABILITY, Cells, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DC6XXX, DCXXXX, DDXXXX, DEXXXX, DXXXXX, EXHIBIT, Gene, Growth, Human, Inserts, MDCK, Patent Category - Biotechnology, Siat7e

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease