Search Results - soumitra+ghosh

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Novel ApoC-11 Mimetic Peptides That Activate LPL for the Treatment of ApoC-11 Deficiency and Hypertriglyceridemia

This technology includes a new class of synthetic peptides that activate Lipoprotein Lipase (LPL), a key plasma enzyme that lowers triglycerides. Mutations in apoC-II is a genetic cause of severe hypertriglyceridemia, which can lead to cardiovascular disease and pancreatitis. The last helical domain (3rd helix) of apoC-ll activates LPL, and we discovered...

Published: 9/11/2024 | Inventor(s): Soumitra Ghosh, Chih-Hung (Larry) Lo, Alan Remaley, Denis Sviridov, Anna Wolska

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Cardiology

ApoE-ApoCII Chimeric Peptides for Treating Hypertriglyceridemia

This technology includes apoE-apoCII chimeric peptides that possess the ability to lower the triglyceride level both in vitro and in vivo. These peptides can be used for treating hypertriglyceridemia and alleviating other diseases and conditions associated with increased triglycerides.

Published: 9/11/2024 | Inventor(s): Soumitra Ghosh, Chih-Hung (Larry) Lo, Alan Remaley, Denis Sviridov, Anna Wolska, Madhav (Matt) Devalaraja

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Cardiology

Anti-sense Therapy Against ApoC-III as a Treatment for High Cholesterol

This technology includes a new class of synthetic peptides that activate Lipoprotein Lipase (LPL), a key plasma enzyme that lowers triglycerides, by displacing apoC-111, a potent inhibitor of LPL. ApoC-11 is a known activator of LPL, whereas ApoC-111 inhibits LPL and raises triglycerides either directly by blocking lipolysis and or by preventing hepatic...

Published: 9/11/2024 | Inventor(s): Soumitra Ghosh, Chih-Hung (Larry) Lo, Alan Remaley, Madhav (Matt) Devalaraja, Denis Sviridov, Anna Wolska

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Cardiology