Search Results - guo-li+ming

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Accelerating Multiview Registration and Iterative Deconvolution to Improve Spatial Resolution and Contrast in Fluorescence Microscopy

This technology includes algorithms and software that improve the speed of iterative deconvolution, a common method for improving spatial resolution and contrast in fluorescence microscopy images. These algorithms also improve the registration of multiview datasets, and apply deep learning to accelerate spatially varying deconvolution.

Published: 8/12/2024 | Inventor(s): Hari Shroff, Yue Li, Yicong Wu, Patrick La Riviere, Min Guo, Huafeng Liu

Keywords(s):

Category(s): Application > Research Materials, Application > Software / Apps, ResearchProducts > Research Equipment

Improvement of Axial Resolution via Photoswitching and Standing Wave Illumination

This technology includes an illuminator and reflector that enables flexible standing wave illumination on an inverted microscope stand, and procedures for using such illumination to improve axial resolution in confocal or instant SIM imaging systems. The axial resolution in conventional fluorescence microscopy is typically limited by diffraction to...

Published: 8/12/2024 | Inventor(s): Hari Shroff, John Giannini, Yicong Wu, Patrick La Riviere, Min Guo, Jiji Chen, Harshad Vishwasrao

Keywords(s):

Category(s): Application > Research Materials, Application > Software / Apps, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment

Computational Alleviation of Depth-dependent Degradation in Fluorescence Images

This technology includes an approach that dramatically lessens the effects of depth-dependent degradation in fluorescence microscopy images. First, we develop realistic ‘forward models’ of the depth dependent degradation and apply these forward models to shallow imaging planes that are expected to be relatively free of such degradation....

Published: 8/12/2024 | Inventor(s): Hari Shroff, Yicong Wu, Min Guo, Patrick La Riviere

Keywords(s):

Category(s): Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software

Instant Total Internal Reflection Fluorescence/Structured Illumination Microscopy (instant TIRF/SIM)

This technology includes a method which enables high-speed, super-resolution microscopy at a very high signal-to-noise ratio (SNR), for biological applications within ~200 nm (the evanescent wave decay length) of a coverslip surface. Instant TIRF/SIM may be implemented simply by modifying and adding to the excitation optics that are already present...

Published: 8/12/2024 | Inventor(s): Hari Shroff, Justin Taraska, Abhishek Kumar, Min Guo

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Research Equipment

Repurposing CDK Inhibitors for the Treatment of Zika Virus Infection

This invention includes the discovery and use of a group of CDK inhibitors that were found during a drug repurposing screen designed to find compounds that inhibit Zika virus caused cell death. The identified CDK inhibitors have all previously been used in clinical trials for other diseases, potentially reducing the long time course needed for new drug...

Published: 7/25/2024 | Inventor(s): Ruili Huang, Miao Xu, Wenwei Huang, Hengli Tang, Emily Lee, Cheng YiChen, Yi Zhou, Hongjun Song, Guo-Li Ming, Zhexing Wen, Wei Zheng

Keywords(s): CDK, Infection, Inhibitors, Repurposing, treatment, VEXXXX, virus, VLXXXX, WIXXXX, WKXXXX, Zika

Category(s): TherapeuticArea > Neurology, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials

Self-Expanding Stent for Valve Replacement

Aortic stenosis and aortic regurgitation are the most common types of aortic valvular diseases. Such diseased aortic valves in the body are traditionally replaced with valve prosthesis by an open surgical implantation. Available for licensing and commercial development is intellectual property covering stents for use with valve prostheses. As illustrated...

Published: 7/25/2024 | Inventor(s): Dumitru Mazilu, Ming Li, Keith Horvath

Keywords(s): AB3AXX, AB3CXX, AB3XXX, ABXXXX, Aortic Retinosis, AXXXXX, Patent Category - Mech/Elect/Soft, Self-expanding, STENT, Valve

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing