Search Results - lysosome

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CNS Therapeutics That Target Neuronal Ceroid-Lipofuscinoses and Thioesterase Deficiency Disorders

Abstract: Clinically known as Neuronal Ceroid-Lipofuscinoses (NCL), Batten disease, is a rare neuron killing disease and one of the lysosomal storage disorders (LSDs). It is associated with a mutation or lack of palmitoyl-protein thioesterase-1 (PPT1) gene. It manifests very early in a child's life causing absence of brain activity as early as 4 years...

Published: 4/8/2024 | Inventor(s): Anil Mukherjee, Chinmoy Sarkar, Gary Zhongjian Zhang

Keywords(s): lysosomal storage disorders (LSD), lysosome, Neuronal Ceroid-Lipofuscinoses (NCL), Non-toxic derivative of hydroxylamine, Palmitoyl-protein thioesterase

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Strategies to Protect Mammalian Neural Tissue Against Cold and Potentially Other Metabolic Stresses and Physical Damages

Abstract: Researchers at the National Eye Institute (NEI) have discovered an invention describing a composition and method(s) of using such composition for preserving viability of cells, tissues, or organs at a low temperature (around 4ºC). Current cold storage solutions or methods for cells, tissues, and organs are suboptimal due to irreversible...

Published: 4/8/2024 | Inventor(s): Jingxing Ou, Wei Li, Kiyoharu Miyagishima

Keywords(s): Cold Storage, Cold-sensitive, Hypothermia, lysosome, Mitochondria, National Eye Institute, NEI, neural injury, Ou, Protein Degradation, TRANSPLANTATION

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Research Materials, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Nephrology