Search Results - trevor+broadt

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Methods of analyzing virus-derived therapeutics

Abstract: Researchers at the National Cancer Institute’s Biopharmaceutical Development Program recently developed massively parallel sequencing methods for virus-derived therapeutics such as viral vaccines and oncolytic immunotherapies. The methods allow for the determination of micro-heterogeneity and quantitation of low frequency sequence variants,...

Published: 7/29/2024 | Inventor(s): Trevor Broadt, Michael Harwich, William Budd, Gregory Meyers

Keywords(s): MAPREC, massively parallel sequencing, MNVT, monkey neurovirulence safety testing, mutant analysis, oncolytic immunotherapy, restriction enzyme cleavage, RNA virus-derived, viral vaccines, virus-derived therapeutic

Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Immunology

Oligonucleotide Production Process

Abstract: This technology provides improved processes for production and purification of nucleic acid-containing compositions, such as non-naturally occurring viruses, for example, recombinant polioviruses that can be employed as oncolytic agents. Some of the improved processes relate to improved processes for producing viral DNA template. Also provided...

Published: 8/14/2024 | Inventor(s): Jianwei Zhu, Samir Shaban, Yueqing Xie, Trevor Broadt, Gautam ("George") Mitra

Keywords(s):

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Formulation of a Modified Stable FGF-1 (TTHX1114) to Accelerate Corneal Endothelium Regeneration

This technology includes the use of a novel formulation for an engineered version of Fibroblast Growth Factor 1 (FGF1), TTHX1114, that can be used to accelerate regeneration of the corneal endothelium after surgical lesions. FGFs are well-established regulators of migration and proliferation of corneal endothelial cells (CECs).

Published: 7/25/2024 | Inventor(s): Vinay Vyas, Hui Fang Dong, Asaf Alimardanov, Gautam ("George") Mitra, Trevor Broadt, David Eveleth

Keywords(s): FGF-1, FORMULATION, Modified, PRESERVATION, STABLE, TTHX1114, VPXXXX, WIXXXX, WKXXXX, XEXXXX

Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, TherapeuticArea > Ophthalmology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Research Materials, TherapeuticArea > Cardiology