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MRI-Based Method for Characterizing Axonal Microstructure in Traumatic Brain Injury

Abstract: Neurites of the central nervous system can be conceptualized as cylindrical pores with finite lengths and radii. In response to physical trauma, axons may assume a “beaded” morphology which alters their ability to conduct electrical impulses, impairing brain function. These microstructural changes are thought to underlie some of the cognitive...

Published: 4/8/2024 | Inventor(s): Peter Basser, Dan Benjamini, Michal Komlosh

Keywords(s): Magnetic Resonance Imaging, MRI, MRI diagnostic, Neurites, Peripheral Nervous System, PNS, TBI, Traumatic Brain Injury

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology

MADCO-Accelerated Multidimensional Diffusion MRI

Abstract: Although multidimensional diffusion/relaxation NMR experiments are widely used in materials sciences and engineering applications, preclinical and clinical MRI applications of these techniques were not feasible. Moreover, higher-field MRI scanners posed another obstacle to translation of this NMR method. Their specific absorption rate (SAR)...

Published: 4/8/2024 | Inventor(s): Peter Basser, Dan Benjamini

Keywords(s): Basser, Biomarkers, Diffusion MRI, IMAGING, Marginal-Distributions, MRI, MRI diagnostic, Multidimensional-NMR, NMR-Spectroscopy, Relaxometry Diffusometry, T1, T2

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Diagnostics

Multidimensional MRI Signature for Specific Detection of Traumatic Brain Injury In Vivo

Abstract: Traumatic brain injury (TBI) represents a major medical, social and economic concern worldwide due to significant mortality – especially among younger populations – and long-term disabilities. Various pathological brain lesions (e.g., intracerebral bleedings, necrotic-ischemic lesions, tissue avulsion) are produced by impacting mechanical...

Published: 4/8/2024 | Inventor(s): Dan Benjamini, Peter Basser, Diego Iacono

Keywords(s): Amyloid Precursor Protein, Be, DAI, Diffuse Axonal Injury, Eunice Kennedy Shriver National Institute of Child Health an, Magnetic Resonance Imaging, MRI, MULTIDIMENSIONAL, NICHD, TAI, TBI, Traumatic Axonal Injury, Traumatic Brain Injury

Category(s): TherapeuticArea > Neurology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics