Search Results - constantine+stratakis

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Treatment of GPR101-Related, Growth Hormone-Related Disorders Such as Gigantism, Dwarfism or Acromegaly

Abstract: Microduplications of the GPR101 gene (located on chromosome Xq26.3 and encodes a G-protein coupled receptor) can result in an excess of growth hormone causing gigantism, that has an onset in early childhood. It is also associated with the growth of sporadic growth hormone producing adenomas in some patients with acromegaly. Current therapies...

Published: 4/8/2024 | Inventor(s): Adrian Daly, Albert Beckets, Fabio Faucz, Giampaolo Trivellin, Constantine Stratakis

Keywords(s): acromegaly, Dwarfism, Eunice Kennedy Shriver National Institute of Child Health an, Gigantism, GPR101, growth hormone regulation, NICHD

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Endocrinology

Tumor Tissues Harboring Mutations in cAMP-specific Phosphodiesterases

Abstract: The National Institute of Child Health and Human Development (NICHD), Division of Intramural Research, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize clinical samples with genetic mutations associated with endocrine tumors. Researchers at the...

Published: 4/8/2024 | Inventor(s): Constantine Stratakis, Anelia Horvath, Kit Man Tsang

Keywords(s): Biomarker, Clinical Samples, Endocrine Tumors, Phosphodiesterase Inhibitors, Research Tools

Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing

Tumor Samples Harboring Novel Stem Cell Factor FOXD3 Variants

Abstract: GISTs are one of the most common sarcomas of the gastrointestinal tract with an estimated 5,000-10,000 new cases in the U.S. reported each year. GISTs affect mainly pediatric and young adult patients, and respond poorly to current therapies. Paragangliomas are rare neuroendocrine neoplasms that develop primarily in the abdomen. Researchers...

Published: 4/8/2024 | Inventor(s): Constantine Stratakis, Anelia Horvath

Keywords(s): FOXD3, Gastrointestinal Tumors (GIST), Paraganglioma Tumors

Category(s): TherapeuticArea > Gastroenterology, Collaboration Sought > Licensing, Application > Research Materials