Search Results - tosato

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Methods for Single Cell Analysis of the Epigenome, Transcriptome, and Genome

Abstract: There are currently no methodologies that allow for epigenome, genome and transcriptome analysis all in a single cell. In addition, there are currently no methodologies that permit repeating the results of these analyses on the same single cells. Scientists at the National Cancer Institute (NCI) Laboratory of Cellular Oncology have developed...

Published: 4/8/2024 | Inventor(s): Giovanna Tosato, Hidetaka Ohnuki

Keywords(s): diagnostic, Epigenomic, Genomic, RESEARCH TOOL, Single Cell Analysis, Tosato, Transcriptomic

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Small Molecule Ephrin (Eph) Tyrosine Kinase Inhibitors for the Treatment of Colorectal Cancer and Other Eph Growth-dependent Solid Tumors

Abstract: Advanced colorectal carcinoma is currently incurable, and new therapies are urgently needed. Ephrin (Eph) receptors are a clinically relevant class of receptor tyrosine kinases. Related signaling pathways are associated with oncogenesis of a number of cancers. NCI investigators found that phosphotyrosine-dependent Eph receptor signaling sustains...

Published: 4/8/2024 | Inventor(s): Giovanna Tosato, Michael Diprima, Harald Schwalbe, Alix Troster, Nathalie Jores, Denis Kudlinzki

Keywords(s): colorectal cancer, Eph Kinase Inhibitors, Eph-related cancers, Ephrin, NVP-BHG712, Regioisomer NVP-Iso, small molecule, solid tumors, Tosato, Tyrosine kinase inhibitors

Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing