HOME
SEARCH
RSS FEED
SUBSCRIBE
New Mouse Strain with Conditional Deletion of SMAD7: Analysis of Disease Processes Involving Immunological, Fibrotic or Cardiovascular Indications
Case ID:
TAB-2099
Web Published:
12/6/2022
Description:
SMAD7 conditional knockout mice are available for licensing. SMAD7 can be knocked out by breeding with CRE-recombinase transgenic mice with a variety of promoters to yield tissue or cell type-specific deletions of SMAD7. SMAD7 has been shown to play a role in bone morphogenesis, cardiovascular tissue generation, immune regulation and fibrosis. Therefore, these mice provide a unique model to examine the role of the SMAD7 gene in disease processes that involve immunological, fibrotic, or cardiovascular components. Specifically, these mice may represent a novel model of Scleroderma, a disease with both an immunological and fibrotic component.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Direct Link:
https://nih.technologypublisher.com/tech?title=New_Mouse_Strain_with_Conditio nal_Deletion_of_SMAD7%3a_Analysis_of_Disease_Processes_Involving_Immunologic al%2c_Fibrotic_or_Cardiovascular_Indications
Category(s):
Collaboration
Licensing
Materials Available
Research Materials
Animal Models
Bookmark this page
Download as PDF
For Information, Contact:
Vidita Choudhry
Technology Development Specialist
NIH Technology Transfer
301-594-4095
vidita.choudhry@nih.gov
Inventors:
Marilyn Diaz
Keywords:
BAXXXX
Chromosome 7, monosomy
Conditional
Deletion
Deletion 7
Gene.
Mouse
RXXXXX
Scleroderma
Scleroderma, systemic
SMAD7
Strain
Home
|
Search
|
RSS
|
Subscribe
© 2024. All Rights Reserved. Powered by
Inteum