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Novel Methods for Reducing Inflammation and Treating Diseases such as Parkinson's and Alzheimer's Disease
Case ID:
TAB-1010
Web Published:
12/6/2022
Description:
Microglia activation leads to inflammation mediated dopaminergic degeneration in the brain of patients with Parkinson and Alzheimer's Disease. Thus Identification of drugs that reduce microglia activation could prevent or reverse neuronal degeneration in these diseases and other degenerative CNS disorders.
This invention describes small-peptide and non-peptide molecules that inhibit microglia activation and prevent neuronal degeneration with a bi-modal dose response curve. The non-peptide compounds have also been shown to prevent dopamine neuronal degeneration in animal models. This invention provides compositions and methods for inhibiting inflammatory mechanisms and treating inflammation-related condition by administering ultra-low (femto-molar) doses of at least one compound of the invention. These compounds include morphinans, opioid peptides, and the tripeptide GGF.
Patent Information:
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Direct Link:
https://nih.technologypublisher.com/tech?title=Novel_Methods_for_Reducing_Inf lammation_and_Treating_Diseases_such_as_Parkinson%27s_and_Alzheimer%27s_Disease
Category(s):
Collaboration
Therapeutics
Neurology
Immunology
Diagnostics
Research Materials
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For Information, Contact:
Vidita Choudhry
Technology Development Specialist
NIH Technology Transfer
301-594-4095
vidita.choudhry@nih.gov
Inventors:
Liya Qin
Guorong Li
MIchelle Block
Wei Zhang
Po-See Chen
Giia-Shuen Peng
Jau-Shyong Hong
Keywords:
Alzheimer disease 1
Alzheimer disease 3
Alzheimer disease 4
Alzheimer disease type 1
Alzheimer disease type 4
Alzheimer disease, familial, type 3
BBXXXX
Discovery
DOSE
femto-molar
IB3XXX
IBXXXX
Inflammation-associated
IXXXXX
Listed LPM Greene as of 4/15/2015
NB1BXX
NBXXXX
NEURODEGENERATIVE
NXXXXX
Parkinson disease 2
Parkinson disease 3
Parkinson disease 9
Parkinson disease, juvenile, autosomal recessive
Parkinson's
Patent Category - Biotechnology
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
Prevention
therapeutic
therapeutics
Ultra-low
VEXXXX
WJXXXX
WKXXXX
YAXXXX
YBXXXX
YCXXXX
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