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Polyclonal Antibodies for the Gbeta5-associated Regulator of G Protein Signaling Protein, RGS7
Case ID:
TAB-2266
Web Published:
12/6/2022
Description:
Researchers at NIDDK have developed polyclonal antibodies against the Regulator of G Protein Signalling (RGS) protein, RGS7. RGS7 binds tightly to Gbeta5, a unique and highly specialized G protein that exhibits much less homology than other Gbeta isoforms (~50%). RGS7 is preferentially expressed in brain and neuroendocrine tissue. Like Gbeta5, RGS7 is expressed prominently in the cell membrane, as well as in the cytosol. Although this distribution pattern suggests that complexes containing Gbeta5 and RGS7 may shuttle information between classical G protein-signaling elements at the plasma membrane and the cell interior, the function of the complex in the brain is largely unknown.
The antibodies were generated in rabbits to a glutathione S-transferase (GST) fusion protein with residues 312-469 of bovine RGS7 (antibody 7RC-1) and react with human and rodent RGS7. The antibodies (7RC-1) can be used for immunoblotting and immunoprecipitation. They can be used to facilitate our understanding of the function of Gbeta5/ RGS7 complexes in brain and neurons.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Polyclonal_Antibodies_for_the_ Gbeta5-associated_Regulator_of_G_Protein_Signaling_Protein%2c_RGS7
Category(s):
Licensing
Research Materials
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For Information, Contact:
Betty Tong
Technology Licensing Specialist
NIH Technology Transfer
301-451-7836
tongb@niddk.nih.gov
Inventors:
Jianhua Zhang
William Simonds
Keywords:
antibodies
BOVINE
box
Fusion
GST
Includes
Protein
Region
RGS
RGS7
RXXXXX
That
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