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Super-Resolution Fluorescence Enhanced Imaging using Bleaching/Blinking Assisted Localization Microscopy (BALM)
Case ID:
TAB-2574
Web Published:
12/6/2022
Description:
The invention relates to systems and methods for localization microscopy for superresolution imaging of fluorescent molecules. The method utilizes intrinsic bleaching/blinking properties of fluorophores in which superresolution is achieved by capturing successive images and subtracting from each either the subsequent image. The location of a single fluorescent molecule can be identified when the molecules either photobleach, blink off, or blink between successive images using a higher magnification lens to achieve a smaller pixel size.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Super-Resolution_Fluorescence_ Enhanced_Imaging_using_Bleaching%2fBlinking_Assisted_Localization_Microscopy_(BALM)
Category(s):
Licensing
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For Information, Contact:
Michael Shmilovich
Senior Licensing And Patenting Manager
NIH Technology Transfer
301-435-5019
shmilovm@nih.gov
Inventors:
Bechara Kachar
Keywords:
AC4XXX
ACXXXX
AXXXXX
BALM
Bleaching/blinking
fluorescent
IMAGING
MICROSCOPY
Superresolution
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