HOME
SEARCH
RSS FEED
SUBSCRIBE
Synergistic Internal Ribosomal Entry Site (IRES)—MicroRNA-Based Approach for Attenuation of Flaviviruses and Live Vaccine Development
Case ID:
TAB-3108
Web Published:
12/6/2022
Description:
Many members of the
Flaviviridae
family are emerging and reemerging human pathogens that have caused outbreaks of devastating and often fatal diseases and represent a serious public health problem on a global scale. There is no single attenuation strategy that exists which is sufficient to prepare a safe, efficacious and immunogenic live attenuated virus vaccine that will work universally for
Flaviviridae
. This patent application claims live attenuated flavivirus vaccines, live attenuated multivalent flavivirus vaccines, and methods of preventing flavivirus infections as well as methods of making the vaccines claimed in the application. More specifically, this patent application claims methods for attenuating a flavivirus or chimeric flavivirus using a synergistic dual strategy involving inserting miRNA-targeting sequences to restrict virus replication in target hosts, cells and/or tissues and placing one or more flavivirus genes under translational control of an internal ribosomal entry site (IRES).
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Direct Link:
https://nih.technologypublisher.com/tech?title=Synergistic_Internal_Ribosomal _Entry_Site_(IRES)%e2%80%94MicroRNA-Based_Approach_for_Attenuation_of_Flaviv iruses_and_Live_Vaccine_Development
Category(s):
Collaboration
Infectious Disease
Research Materials
Vaccines
Bookmark this page
Download as PDF
For Information, Contact:
Peter Soukas
Technology Licensing Specialist/TTPS
NIH Technology Transfer
301-496-2644
peter.soukas@nih.gov
Inventors:
Konstantin Tsetsarkin
Alexander Pletnev
Keywords:
Approach
ATTENUATION
DC1XXX
DC5BXX
DC5XXX
DC6XXX
DCXXXX
DD1XXX
DDXXXX
Development
DEXXXX
DXXXXX
ENTRY
FLAVIVIRUSES
INTERNAL
Live
Pnd
RIBOSOME
Site/microRNA-based
Synergistic
Vaccine
Zika
Home
|
Search
|
RSS
|
Subscribe
© 2024. All Rights Reserved. Powered by
Inteum