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Systems and Methods to Automatically Detect Ellipsoid Zone Loss in SD-OCT Imaging

Summary: The National Eye Institute (NEI) seeks research co-development partners and/or licensees for an automatic deep learning-based algorithm to detect and quantitate ellipsoid zone (EZ) loss in Spectral Domain Optical Coherence Tomography (SD-OCT) images. Description of Technology: The present disclosure generally relates a method of automatically...

Published: 3/11/2026 | Inventor(s): Wathudurage De Silva, Catherine Cukras

Keywords(s):

Category(s): Application > Software / Apps, TherapeuticArea, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Real-time AI System for Echocardiography Analysis and Quantification

Summary: We are seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize this technology. Description of Technology: Scientists have developed an artificial intelligence (AI) system to automatically extract predictive biomarkers from echocardiography. This AI system...

Published: 2/18/2026 | Inventor(s): Ghada Alzamzmi, Sameer Antani, Li-Yueh Hsu, Vandana Sachdev, Sivarama Krishnan Rajaraman

Keywords(s):

Category(s): Application > Diagnostics, TherapeuticArea > Cardiology, Collaboration Sought > Collaboration, Application > Software / Apps

Mass Spectrometry Derived Protein Biomarkers of Atherosclerotic Cardiovascular Disease Risk

This technology includes a combination of protein biomarkers and clinical risk factors to be used as an In Vitro Diagnostic Multivariate Index Assay (IVDMIA) that can improve the identification of individuals at high risk for atherosclerotic cardiovascular disease (ASCVD) and myocardial infarction (MI). Incorporation of novel protein biomarkers of ASCVD...

Published: 8/12/2024 | Inventor(s): Daniel Levy, Martin Larson, Aram Adourian, Pieter Muntendam

Keywords(s):

Category(s): Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, TherapeuticArea > Cardiology

An Automated System for Myocardial Perfusion Mapping and Machine Diagnosis to Detect Ischemic Heart Disease with First-pass Perfusion Cardiac Magnetic Resonance Imaging

This technology includes a fully automated computer aided diagnosis system to quantify myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) pixel maps from the first-pass contrast-enhanced cardiac magnetic resonance (CMR) perfusion images. This system performs automated image registration, motion compensation, segmentation, and modeling...

Published: 5/12/2025 | Inventor(s): Li-Yueh Hsu, Andrew Arai, Matthew Jacobs, Mitchel Benovoy

Keywords(s):

Category(s): Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology

Background-free Imaging by Selective Modulation of Nanodiamond Fluorescence Using a Magnetic Field

This technology includes the use of nanodiamonds to achieve background-free imaging. We present several techniques to reduce or eliminate background florescence by exploiting properties of the fluorescent nanodiamonds. In particular, magnetic field modulation of the fluorescence intensity offers a simple, robust, and easily adaptable method to obtain...

Published: 8/12/2024 | Inventor(s): Ambika Bumb, Susanta Sarkar, Keir Neuman

Keywords(s):

Category(s): Application > Diagnostics, Application > Medical Devices, Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment

A Pre-emphasis Technique Based on the Temperature-dependent Gradient System Behavior for Trajectory Correction in MR Imaging

This technology includes the determination of temperature dependent temporal deviations of the real from the intended gradient waveforms and k-space trajectories during MRI image acquisition, and the use of appropriate temperature dependent pre-compensations to avoid or reduce the image distortion caused by these temporal deviations on the gradient...

Published: 8/12/2024 | Inventor(s): Adrienne Campbell-Washburn

Keywords(s):

Category(s): Application > Medical Devices, Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software

A Method to Remove Fluid-motion Related Artifacts in Magnetic Resonance Thermometry Images Using Magnetic Field Gradients

This technology includes the incorporation of a magnetic field gradient waveform (consisting of two or more pulses) between excitation and encoding to eliminate signal from moving fluid for imaging applications. Proton Resonance Frequency (PRF) thermometry is a widely used Magnetic Resonance Imaging (MRI) based technique to monitor changes in tissue...

Published: 1/16/2026 | Inventor(s): Sunil Patil, Adrienne Campbell-Washburn, Waqas Majeed, Himanshu Bhat

Keywords(s):

Category(s): Application > Research Materials, Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software

A Principal Component Analysis Based Multi-baseline Phase Correction Method for PRF Thermometry

This technology includes a novel Principal Component Analysis (PCA) based approach to correct motion related B0 changes in PRF thermometry. Proton Resonance Frequency (PRF) thermometry is a widely used Magnetic Resonance Imaging (MRI) based technique to monitor changes in tissue temperature in response to thermal therapy. The use of PRF thermometry...

Published: 1/16/2026 | Inventor(s): Adrienne Campbell-Washburn, Waqas Majeed, Rainer Schneider, Himanshu Bhat

Keywords(s):

Category(s): Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software

Isotopes of Alpha Ketoglutarate and Related Compounds for Hyperpolarized MRI Imaging

This technology includes 1-13C-ketoglutarate which can be used for imaging the conversion to hydroxyglutarate (HG) or Gln in cancer cells with an IDH1 mutations by hyperpolarized MRI. The ability to detect the status of IDH1 mutations is clinically prognostic for multiple cancers. These exciting observations are limited by two factors, the major one...

Published: 8/13/2025 | Inventor(s): Rolf Swenson, Deepak Sail

Keywords(s):

Category(s): Application > Diagnostics, Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment, TherapeuticArea > Oncology

Prior Enhanced Compressed Sensing (PRINCE-CS) Reconstruction for Dynamic 2D-radial Cardiac MRI

This technology includes a method to reduce scanning time while retaining high image quality during MRI scans. A reconstructed image is rendered from a set of MRI data by first estimating an image with an area which does not contain artifacts or has an artifact with a relatively small magnitude. Corresponding data elements in the estimated image and...

Published: 8/12/2024 | Inventor(s): Ti-chiun Chang, Mariappan Nadar, Jens Guhring, Michael Zenge, Kai Block, Peter Speier

Keywords(s):

Category(s): Application > Diagnostics, Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software

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