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Renal Selective Unsaturated Englerin Analogues

Abstract: Englerin A, a natural product, has shown growth-inhibiting activity against renal cancer cell lines. The compound is an agonist of protein kinase C (PCK) theta, which results in cell cytotoxicity, insulin inhibition, and selective activation of viral replication in T cells. Englerin A derivatives are promising treatment strategies for any...

Published: 4/8/2024 | Inventor(s): John Beutler, Tanya Ransom, Antonio Echavarren, Frederic Ratel

Keywords(s): Beutler, DIABETES, HIV, renal cancer, small molecule

Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease