Search Results - beutler

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Methods For Treating or Preventing Inflammation and Periodontitis

Abstract: Bone-loss-related diseases, such as periodontitis, are characterized by an imbalance between the formation and activity of osteoblasts and osteoclasts, leading to bone loss. There are several signaling pathways that participate in the osteoclastogenesis process. Finding inhibitors of these pathways and other osteoclastogenesis-related pathways...

Published: 4/8/2024 | Inventor(s): John Beutler, Marcos Da Cunha, Pedro Rosalan, Marcelo Franchin

Keywords(s): Beutler, Bone Loss, Cinnamolyoxy-mammeisin, CNM, Geopropolis, Osteoclastogeneis, PERIODONTITIS

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology

Renal Selective Unsaturated Englerin Analogues

Abstract: Englerin A, a natural product, has shown growth-inhibiting activity against renal cancer cell lines. The compound is an agonist of protein kinase C (PCK) theta, which results in cell cytotoxicity, insulin inhibition, and selective activation of viral replication in T cells. Englerin A derivatives are promising treatment strategies for any...

Published: 4/8/2024 | Inventor(s): John Beutler, Tanya Ransom, Antonio Echavarren, Frederic Ratel

Keywords(s): Beutler, DIABETES, HIV, renal cancer, small molecule

Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease

Schweinfurthins and Uses Thereof

Abstract: Neurofibromatosis type 1 (NF1) is a genetic disorder affecting 1 per 3000 individuals on average. Patients develop a variety of developmental benign and malignant pathologies. The most common tumors associated with NF1 are peripheral sheath tumors, including neurofibromas, optical gliomas, and malignant peripheral nerve sheath tumors. Researchers...

Published: 4/8/2024 | Inventor(s): Karlyne Reilly, David Wiemer, John Beutler, Thomas (Tommy) Turbyville

Keywords(s): Beutler, Neurofibromas, Neurofibromatosis, Schweinfurthin

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Collaboration