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Transgenic Mice Expressing CNO-sensitive Gq- or Gs-coupled Designer Receptors Selectively in Pancreatic Beta Cells

Impaired functioning of pancreatic beta cells is a key hallmark of type 2 diabetes. Beta cell function is modulated by the actions of different classes of heterotrimeric G proteins. The functional consequences of activating specific beta cell G protein signaling pathways in vivo are not well understood at present, primarily due to the fact that beta...

Published: 7/25/2024 | Inventor(s): Jean-Marc Guettier, Jurgen Wess

Keywords(s): =, Beta-RASSL-1, Beta-RASSL-2, ID1XXX, Mice, RIPII-RQ, RIPII-Rs, TRANSGENIC, VFXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Endocrinology, Application > Research Materials