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Transgenic Mice Overexpressing Islet Beta Cell M3 Muscarinic Acetylcholine Receptors

Researchers at NIH have generated transgenic mice in which the M3 muscarinic receptor is overexpressed in pancreatic beta cells. This was done by placing the receptor gene under the control of the 650 bp rat insulin promoter II (RIP II). The resulting mice show a pronounced increase in glucose tolerance and enhanced plasma insulin levels. Strikingly,...

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): ACETYLCHOLINE, Beta, Cell, IDXXXX, ISLET, IXXXXX, M3, Mice, MUSCARINIC, Overexpressing, RECEPTORS, TRANSGENIC

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials

Transgenic Mice with Constitutively Active M3 Muscarinic Receptor in Islet Beta Cells

Q490L point mutation was introduced into the rat M3 muscarinic receptor cDNA to confer persistent, constitutive (ligand-independent) activity. Expression of the M3 receptor mutant was placed under the control of a 650 bp fragment of the rat insulin promoter II (RIP II) to limit expression to the islet beta cell.

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): Active, Beta, Cells, CONSTITUTIVELY, IDXXXX, ISLET, IXXXXX, M3, Mice, MUSCARINIC, RECEPTOR, TRANSGENIC

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials

Islet Beta Cell Only M3 Muscarinic Acetylcholine Receptor Knockout Mouse

Researchers at NIH have developed islet beta cell M3 muscarinic acetylcholine receptor knockout mouse. The mice were generated by crossing floxed mouse M3 muscarinic acetylcholine receptor mice with mice in which Cre recombinase was controlled by the beta-cell specific rat insulin promoter (RIP-Cre mice).

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): ACETYLCHOLINE, Beta, Cell, IDXXXX, ISLET, IXXXXX, Knockout, M3, MUSCARINIC, RECEPTOR

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

M3 Muscarinic Receptor Knockout Mice (Chrm3 tm1Jwe) for the Study of Obesity and Other Metabolic Disorders

The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M3 muscarinic ACh receptors are present in the central nervous system and the periphery. M3R knockout mice are viable and fertile, and have no major morphological abnormalities. They have a lean phenotype due to a combination of reduced caloric intake and...

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): ACXXXX, AXXXXX, Discovery, DOUBLE, DRUG, Generation, ID1XXX, IDXXXX, IXXXXX, KnockoutKO, M1/M3, M1/M4, M2/M3, M2/M4, Mice:, MUSCARINIC, Novel, RECEPTOR, TOOLS

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

M5 Muscarinic Receptor Knockout (Chrm5tm1Jwe) Mouse Model for Neurological Studies

M5 muscarinic receptor knockout: Deficiency of M5Rs reduces drug-seeking behavior. The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to Gi/Go. M5R knockout mice are viable and fertile, and have no major morphological abnormalities. M5...

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): Chrm5, Knock, M5, Mouse, MUSCARINIC, NCXXXX, NXXXXX, RECEPTOR, TmJwe

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Neurology

Transgenic Mice Expressing CNO-sensitive Gq- or Gs-coupled Designer Receptors Selectively in Pancreatic Beta Cells

Impaired functioning of pancreatic beta cells is a key hallmark of type 2 diabetes. Beta cell function is modulated by the actions of different classes of heterotrimeric G proteins. The functional consequences of activating specific beta cell G protein signaling pathways in vivo are not well understood at present, primarily due to the fact that beta...

Published: 7/25/2024 | Inventor(s): Jean-Marc Guettier, Jurgen Wess

Keywords(s): =, Beta-RASSL-1, Beta-RASSL-2, ID1XXX, Mice, RIPII-RQ, RIPII-Rs, TRANSGENIC, VFXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Endocrinology, Application > Research Materials

Conditional V2 Vasopressin Receptor Mutant Mice as a Model to Study X-linked Nephrogenic Diabetes Insipidus (XNDI)

X-linked nephrogenic diabetes insipidus (XNDI) is a severe kidney disease caused by inactivating mutations in the V2 vasopressin receptor (V2R) gene that result in the loss of renal urine-concentrating ability. At present, no specific pharmacological therapy has been developed for XNDI, primarily due to the lack of suitable animal models. This technology...

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): ACXXXX, AXXXXX, Chromosome 7, monosomy, Conditional, Deletion 7, DIABETES, Insipidus, Mice, MUTANT, Nephrogenic, Nephrogenic diabetes insipidus, Novel, RECEPTOR, RXXXXX, STRATEGY, Studied, treatment, V2, VASOPRESSIN, X-LINKED

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials