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Transgenic Mice with Constitutively Active M3 Muscarinic Receptor in Islet Beta Cells

Q490L point mutation was introduced into the rat M3 muscarinic receptor cDNA to confer persistent, constitutive (ligand-independent) activity. Expression of the M3 receptor mutant was placed under the control of a 650 bp fragment of the rat insulin promoter II (RIP II) to limit expression to the islet beta cell.

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): Active, Beta, Cells, CONSTITUTIVELY, IDXXXX, ISLET, IXXXXX, M3, Mice, MUSCARINIC, RECEPTOR, TRANSGENIC

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials