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Propionyl-CoA Carboxylase Beta (PCCB) Alleles in Propionic Acidemia (PA) mouse models

Propionic acidemia (PA) is an autosomal recessive metabolic disorder caused by mutations in either Propionyl-CoA carboxylase alpha (PCCA) or Propionyl-CoA carboxylase beta (PCCB). The products of these genes form the alpha and beta subunits of the enzyme propionyl-Co A carboxylase (PCC), a critically important mitochondrial enzyme involved in the catabolism...

Published: 7/25/2024 | Inventor(s): Randy Chandler, Charles Venditti

Keywords(s): Acidemia, ALLELES, Beta, Carboxylase, PA, Pccb, Propionic, Propionyl-CoA, VPXXXX, WIXXXX, XEXXXX

Category(s): Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, Application > Research Materials

Transgenic Mice Overexpressing Islet Beta Cell M3 Muscarinic Acetylcholine Receptors

Researchers at NIH have generated transgenic mice in which the M3 muscarinic receptor is overexpressed in pancreatic beta cells. This was done by placing the receptor gene under the control of the 650 bp rat insulin promoter II (RIP II). The resulting mice show a pronounced increase in glucose tolerance and enhanced plasma insulin levels. Strikingly,...

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): ACETYLCHOLINE, Beta, Cell, IDXXXX, ISLET, IXXXXX, M3, Mice, MUSCARINIC, Overexpressing, RECEPTORS, TRANSGENIC

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials

Transgenic Mice with Constitutively Active M3 Muscarinic Receptor in Islet Beta Cells

Q490L point mutation was introduced into the rat M3 muscarinic receptor cDNA to confer persistent, constitutive (ligand-independent) activity. Expression of the M3 receptor mutant was placed under the control of a 650 bp fragment of the rat insulin promoter II (RIP II) to limit expression to the islet beta cell.

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): Active, Beta, Cells, CONSTITUTIVELY, IDXXXX, ISLET, IXXXXX, M3, Mice, MUSCARINIC, RECEPTOR, TRANSGENIC

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials

Islet Beta Cell Only M3 Muscarinic Acetylcholine Receptor Knockout Mouse

Researchers at NIH have developed islet beta cell M3 muscarinic acetylcholine receptor knockout mouse. The mice were generated by crossing floxed mouse M3 muscarinic acetylcholine receptor mice with mice in which Cre recombinase was controlled by the beta-cell specific rat insulin promoter (RIP-Cre mice).

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): ACETYLCHOLINE, Beta, Cell, IDXXXX, ISLET, IXXXXX, Knockout, M3, MUSCARINIC, RECEPTOR

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics