Search Results - acetylcholine

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Transgenic Mice Overexpressing Islet Beta Cell M3 Muscarinic Acetylcholine Receptors

Researchers at NIH have generated transgenic mice in which the M3 muscarinic receptor is overexpressed in pancreatic beta cells. This was done by placing the receptor gene under the control of the 650 bp rat insulin promoter II (RIP II). The resulting mice show a pronounced increase in glucose tolerance and enhanced plasma insulin levels. Strikingly,...

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): ACETYLCHOLINE, Beta, Cell, IDXXXX, ISLET, IXXXXX, M3, Mice, MUSCARINIC, Overexpressing, RECEPTORS, TRANSGENIC

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials

Islet Beta Cell Only M3 Muscarinic Acetylcholine Receptor Knockout Mouse

Researchers at NIH have developed islet beta cell M3 muscarinic acetylcholine receptor knockout mouse. The mice were generated by crossing floxed mouse M3 muscarinic acetylcholine receptor mice with mice in which Cre recombinase was controlled by the beta-cell specific rat insulin promoter (RIP-Cre mice).

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): ACETYLCHOLINE, Beta, Cell, IDXXXX, ISLET, IXXXXX, Knockout, M3, MUSCARINIC, RECEPTOR

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics