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M5 Muscarinic Receptor Knockout (Chrm5tm1Jwe) Mouse Model for Neurological Studies

M5 muscarinic receptor knockout: Deficiency of M5Rs reduces drug-seeking behavior. The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to Gi/Go. M5R knockout mice are viable and fertile, and have no major morphological abnormalities. M5...

Published: 7/25/2024 | Inventor(s): Jurgen Wess

Keywords(s): Chrm5, Knock, M5, Mouse, MUSCARINIC, NCXXXX, NXXXXX, RECEPTOR, TmJwe

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Neurology