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Methods for Prevention and Treatment of Polyomavirus Infection or Reactivation (E-179-2007)

Available for licensing and commercial development are methods of using Tranilast [N-(3',4'-dimethoxycinnamoyl)anthranilic acid] in the prevention and treatment of human polyomavirus infection. Treatment with Tranilast decreases viral protein expression for two human polyomavirus species, JC virus (JCV) and BK virus (BKV). Furthermore, the increase...

Published: 4/8/2024 | Inventor(s): Jeffrey Kopp, Eugene Major, Veerasamy Ravichandran

Keywords(s): BBXXXX, BK, BKV, DB4XXX, DBXXXX, DXXXXX, HIV AIDS, IMMUNOCOMPROMISED, Infection, inhibitor, JC, JCV, leukoencephalopathy, lymphoma, nephrophathy, PML, polyomavirus, Polyomavirus Infections, Polyomaviruses, Progressive multifocal leukoencephalopathy, TGF-B, Tranilast, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics

Methods for Prevention and Treatment of Polyomavirus Infection or Reactivation

Available for licensing and commercial development are methods of using two MAP kinase kinase (MEK) inhibitors, PD98059 and U0126, in the prevention and treatment of polyomavirus infection. Decrease in viral protein expression upon treatment with the MEK inhibitors has been demonstrated for two polyomavirus species, JC virus (JCV) and BK virus (BKV)....

Published: 4/8/2024 | Inventor(s): Eugene Major, Veerasamy Ravichandran

Keywords(s): BBXXXX, BK, BKV, DB4BXX, DB4XXX, DBXXXX, DXXXXX, EFFECTOR, Idenitification, Infection, Infections;, inhibitor, Inhibitors, JC, JCV, lymphoma, MAP-kinase-, MEK, PD98059, Polyomavirus Infections, Progressive multifocal leukoencephalopathy, U0126, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics