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SMAD3 Reporter Mouse for Assessing TGF-ß/Activin Pathway Activation

Abstract: The Transforming Growth Factor Beta (TGF-ß) ligands (i.e., TGF-ß1, -ß2, -ß3) are key regulatory proteins in animal physiology. Disruption of normal TGF-ß signaling is associated with many diseases from cancer to fibrosis. In mice and humans, TGF-ß activates TGF-ß receptors (e.g., TGFBR1), which activates SMAD proteins that alter gene expression...

Published: 5/23/2024 | Inventor(s): Lalage Wakefield, Yu-an Yang, Sushil Rane, Caroline Hill

Keywords(s): Animal Model, CANCER, EGFP, Fibrosis, Wakefield, mothers against decapentaplegic homolog 3, Oncology, Reporter Mouse, SMAD3, TGF-ß, Transforming Growth Factor Beta

Category(s): TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, TherapeuticArea > Neurology