Search Results - lalage+wakefield

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SMAD3 Reporter Mouse for Assessing TGF-ß/Activin Pathway Activation

Abstract: The Transforming Growth Factor Beta (TGF-ß) ligands (i.e., TGF-ß1, -ß2, -ß3) are key regulatory proteins in animal physiology. Disruption of normal TGF-ß signaling is associated with many diseases from cancer to fibrosis. In mice and humans, TGF-ß activates TGF-ß receptors (e.g., TGFBR1), which activates SMAD proteins that alter gene expression...

Published: 5/23/2024 | Inventor(s): Lalage Wakefield, Yu-an Yang, Sushil Rane, Caroline Hill

Keywords(s): Animal Model, CANCER, EGFP, Fibrosis, Wakefield, mothers against decapentaplegic homolog 3, Oncology, Reporter Mouse, SMAD3, TGF-ß, Transforming Growth Factor Beta

Category(s): TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, TherapeuticArea > Neurology

Reporter Plasmid to Identify Cancer Stem Cells

Abstract: Cancer stem cells are a minority population of cells in tumors that initiate and sustain the cancer and which are resistant to therapy; they may cause tumors to recur after curative treatment. Current therapies generally do not target cancer stem cells. Scientists at the National Cancer Institute Laboratory of Cancer Biology and Genetics...

Published: 5/23/2024 | Inventor(s): Lalage Wakefield, Binwu Tang

Keywords(s): Lentiviral, Oct4, PLASMID, reporter construct, Sox2

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials

Immunocompetent Mouse Model for Tracking Cancer Progression

Abstract: The National Cancer Institute seeks interested parties to co-develop transgenic mice having immunocompetent rat growth hormone-firefly Luciferase-enhanced green fluorescent protein. The technology is a transgenic mouse model tolerized to firefly Luciferase (ffLuc)- and enhanced green fluorescent protein (eGFP)-labeled tissue whilst maintaining...

Published: 5/23/2024 | Inventor(s): Glenn Merlino, Chi-Ping Day, Lalage Wakefield

Keywords(s): Achondroplasia, Bioimaging, Immunocompetent, Rat growth hormone

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Research Materials