Search Results - achondroplasia

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Immunocompetent Mouse Model for Tracking Cancer Progression

Abstract: The National Cancer Institute seeks interested parties to co-develop transgenic mice having immunocompetent rat growth hormone-firefly Luciferase-enhanced green fluorescent protein. The technology is a transgenic mouse model tolerized to firefly Luciferase (ffLuc)- and enhanced green fluorescent protein (eGFP)-labeled tissue whilst maintaining...

Published: 5/23/2024 | Inventor(s): Glenn Merlino, Chi-Ping Day, Lalage Wakefield

Keywords(s): Achondroplasia, Bioimaging, Immunocompetent, Rat growth hormone

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Research Materials

Fibroblast Growth Factor 3 (FGFR3) Receptor Knockin Mice

Missense mutations in Fibroblast Growth Factor Receptor 3 (FGFR3) result in several human skeletal dysplasias, including the most common form of dwarfism, achondroplasia. The NIH announces the generation of FGFR3 knockin mice, which have a Gly369Cys mutation, inserted into the mouse genome. Phenotypic analysis of the mice reveals that the FGF/FGFR3...

Published: 4/8/2024 | Inventor(s): Chuxia Deng

Keywords(s): Achondroplasia, Dwarfism, RXXXXX, Skeletal dysplasias

Category(s): Collaboration Sought > Licensing, Application > Research Materials