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Scalable Purification of AAV2, AAV4 or AAV5 Using Ion-Exchange Chromatography

Adeno-associated viruses (AAVs) constitute, as a group, the vehicle of choice for gene therapy because of several attractive features. Among others, AAVs are less pathogenic than other viruses, and they can be used for the long-term expression of therapeutic genes. This invention describes a simple ion-exchange (HPLC) methodology to purify different...

Published: 10/28/2024 | Inventor(s): John (Jay) Chiorini, Nikola Kaludov

Keywords(s): AAV2, AAV4, AAV5, CHROMATOGRAPHY., GB2DXX, GB2XXX, GBXXXX, GXXXXX, ION-EXCHANGE, purification, SCALABLE

Category(s): Application > Therapeutics