Search Results - aav2

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Scalable Purification of AAV2, AAV4 or AAV5 Using Ion-Exchange Chromatography

Adeno-associated viruses (AAVs) constitute, as a group, the vehicle of choice for gene therapy because of several attractive features. Among others, AAVs are less pathogenic than other viruses, and they can be used for the long-term expression of therapeutic genes. This invention describes a simple ion-exchange (HPLC) methodology to purify different...

Published: 10/28/2024 | Inventor(s): John (Jay) Chiorini, Nikola Kaludov

Keywords(s): AAV2, AAV4, AAV5, CHROMATOGRAPHY., GB2DXX, GB2XXX, GBXXXX, GXXXXX, ION-EXCHANGE, purification, SCALABLE

Category(s): Application > Therapeutics

Production of Adeno-Associated Viruses in Insect Cells

Adeno-associated virus (AAV) is being developed for gene therapy applications. This virus type presents several advantages over alternate vectors for therapeutic gene delivery. AAV is not considered pathogenic and transduces stably dividing and non-dividing cells. AAV also shows good serotype specificity to various cell types for targeted gene delivery. The...

Published: 10/28/2024 | Inventor(s): Robert Kotin

Keywords(s): AAV, AAV1, AAV2, AAV5, Adeno-associated, CB2AXX, CB2XXX, CBXXXX, Cells, CXXXXX, Duke DNA Project, GB2A2X, GB2AXX, GB2XXX, GBXXXX, GENE THERAPY, GXXXXX, insect, production, virus

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics