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Cloning and Characterization of an Avian Adeno-Associated Virus and Uses Thereof

Currently, adeno-associated virus (AAV) represents the gene therapy vehicle of choice because it has many advantages over current strategies for therapeutic gene insertion. AAV is less pathogenic than other virus types; stably integrates into dividing and non-dividing cells; integrates at a consistent site in the host genome; and shows good specificity...

Published: 7/25/2024 | Inventor(s): John (Jay) Chiorini, Ioannis Bossis

Keywords(s): GB2A2X, GB2AXX, GB2XXX, GB3XXX, GBXXXX, GXXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

AAV4 Vector And Uses Thereof

These patent applications describe the cloning and characterization of the full-length genome of adeno-associated virus type 4 (AAV4). AAV4, like other members of the AAV family, may be useful as a vector for gene therapy. When compared to AAV2, AAV4 may be better suited as a vector due to its larger size -- which permits efficient encapsidation of...

Published: 7/25/2024 | Inventor(s): John (Jay) Chiorini, Robert Kotin, Brian Safer

Keywords(s): GB3XXX, GBXXXX, GXXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics