Search Results - gene+expression

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Abstract: Gene therapies offer promising prospects of treating a wide variety of human diseases. In one method, a gene therapy vector can be utilized to deliver an unmutated copy of a gene, called a transgene, to replace a mutated gene in order to treat the genetic disorder. However, lack of expression of a therapeutic transgene and uncontrolled gene...

Published: 4/8/2024 | Inventor(s): Mirit Aladjem, Cindy Tseng, Haiquing Fu, Lixin Wang

Keywords(s): Aladjem, delivery system, DNA replication initiation, GENE EXPRESSION, Gene Silencing Modulation, GENE THERAPY, Replicators, TRANSGENE

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Collaboration

Molecular Classification of Primary Mediastinal Large B Cell Lymphoma Using Formalin-Fixed, Paraffin-Embedded Tissue Specimens

Abstract: Primary mediastinal B-cell lymphoma (PMBCL) is an aggressive type of non-Hodgkin lymphoma that mostly occurs in people between the ages of 30-40. It accounts for 5-7% of all aggressive lymphomas. The diagnosis of PMBCL is challenging as the histological features of PMBCL overlap with diffuse large B-cell lymphoma (DLBCL), another most common...

Published: 4/8/2024 | Inventor(s): Louis Staudt, Lisa Rimsza, David Scott, George Wright, Anja Mottok, Christian Steid, Elaine Jaffe, Randy Gascoyne, Elias Guerri, Elias Guerri, Elias Guerri, Andreas Rosenwald, Kai Fu, Timothy Greiner, Erlend Smeland, Jan Delabie, Rita Braziel, Wing Chan, Joo Song, Dennis Weisenburger, German Ott, James Cook

Keywords(s): assay, Diffuse Large B Cell Lymphoma, DLBCL, FFPE, Formalin-fixed, GENE EXPRESSION, paraffin-embedded biopsies, PMBCL, Primary Mediastinal Large B Cell Lymphoma, Staudt

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics