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Small Molecule Inhibitors of Histone Demethylases for Treating Rhabdomyosarcoma (RMS) and Other Cancers

Abstract: Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children and makes up 3% of all childhood cancers. Aveloar Rhabdomyosarcoma is the most aggressive subtype and is primarily established through a chromosomal translocation resulting in the fusion protein PAX3-FOXO1. Despite aggressive therapy, the 5-year survival rate...

Published: 4/8/2024 | Inventor(s): Javed Khan, Robert Hawley, Megan Peach, Girma Woldemichael

Keywords(s): Histone Lysine Demethylases, KDM3B, KDM3B inhibitors, KDMs, Khan, Lysine Demethylase 3B, PAX3-FOXO1, Rhabdomyosarcoma, RMS

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Neurology