Search Results - khan

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Small Molecule Inhibitors of Histone Demethylases for Treating Rhabdomyosarcoma (RMS) and Other Cancers

Abstract: Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children and makes up 3% of all childhood cancers. Aveloar Rhabdomyosarcoma is the most aggressive subtype and is primarily established through a chromosomal translocation resulting in the fusion protein PAX3-FOXO1. Despite aggressive therapy, the 5-year survival rate...

Published: 4/8/2024 | Inventor(s): Javed Khan, Robert Hawley, Megan Peach, Girma Woldemichael

Keywords(s): Histone Lysine Demethylases, KDM3B, KDM3B inhibitors, KDMs, Khan, Lysine Demethylase 3B, PAX3-FOXO1, Rhabdomyosarcoma, RMS

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Neurology

Fibroblast Growth Factor Receptor 4 (FGFR4) Monoclonal Antibodies and Methods of Their Use

Abstract: Several Fibroblast Growth Factor Receptor 4 (FGFR4) specific antibodies with binding affinity at the nanomolar range have been successfully developed at the Genetics Branch. These antibodies have been made into different formats of therapeutic including Antibody Drug Conjugate (ADC), Bispecific T cell engager (BiTE) ae well as Chimeric Antigen...

Published: 4/8/2024 | Inventor(s): Javed Khan, Sivasubramanian Baskar, Dimiter Dimitrov, Zhongyu Zhu, Rimas Orentas, Adam Cheuk

Keywords(s): FGFR4, Fibroblast Growth Factor Receptor 4, Immunotherapy, Khan, Monoclonal Antibodies, Rhabdomyosarcoma, RMS

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology