Search Results - monoclonal+antibodies

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Anti-Mesothelin Monoclonal Antibodies for the Treatment of Cancer

Abstract: The National Cancer Institute seeks parties interested in collaborative research to further co-develop monoclonal antibodies for the treatment of mesothelin-expressing cancers. The antibody was able to inhibit tumor growth in mouse xenograft models, and corresponding immunotoxins were able to inhibit tumor cell growth in vitro Mesothelin is...

Published: 5/21/2024 | Inventor(s): Mitchell Ho, Ira Pastan, Dimiter Dimitrov, Zhewei Tang, Mingqian Feng, Wei Gao

Keywords(s): Epitopes, MESOTHELIN, Monoclonal Antibodies

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Fibroblast Growth Factor Receptor 4 (FGFR4) Monoclonal Antibodies and Methods of Their Use

Abstract: Several Fibroblast Growth Factor Receptor 4 (FGFR4) specific antibodies with binding affinity at the nanomolar range have been successfully developed at the Genetics Branch. These antibodies have been made into different formats of therapeutic including Antibody Drug Conjugate (ADC), Bispecific T cell engager (BiTE) ae well as Chimeric Antigen...

Published: 4/8/2024 | Inventor(s): Javed Khan, Sivasubramanian Baskar, Dimiter Dimitrov, Zhongyu Zhu, Rimas Orentas, Adam Cheuk

Keywords(s): FGFR4, Fibroblast Growth Factor Receptor 4, Immunotherapy, Khan, Monoclonal Antibodies, Rhabdomyosarcoma, RMS

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Antibodies Against TL1A, a TNF-Family Cytokine, for the Treatment and Diagnosis of Autoimmune Inflammatory Diseases

Autoimmune inflammatory diseases occur in greater than five percent of the United States population; this disease group includes asthma, multiple sclerosis, rheumatoid arthritis, and lupus. Treatments generally include immunosuppressants or anti-inflammatory drugs, which can have serious side effects; recently, more specific immunomodulatory therapies...

Published: 7/30/2024 | Inventor(s): Francoise Meylan, Yun-Jeong Song, Richard Siegel

Keywords(s): antibodies, ANTIBODY, ANTI-HUMAN, Anti-mouse, Autoimmune, diagnostic, DR3, IA3XXX, IAXXXX, IB3XXX, IBXXXX, Immunomodulation, immuno-modulator, immunomodulatory, INFLAMMATORY, inflammatory disease, IXXXXX, monoclonal, Monoclonal Antibodies, Monoclonal Antibody, Patent Category - Biotechnology, therapeutic, TL1A, tnf, TNFRSF25, TNFSF15, tumor necrosis factor, USES

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Immunology