Search Results - kenner+rice

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Novel Biased Potent Opioid-Like Agonists as Improved Medications to Treat Chronic and Acute Pain

Abstract: There are no analgesics to ameliorate chronic pain without adverse side-effects (e.g., respiratory depression, gastrointestinal effects, tolerance, dependence), thus forcing patients into a difficult choice of negative impacts on quality of life. Most of the analgesics used for chronic and acute pain are drugs such as oxycodone, morphine,...

Published: 4/8/2024 | Inventor(s): Kenner Rice, Arthur Jacobson, Fuying Li

Keywords(s): Chronic Pain Treatment, G-protein biased, National Institute on Drug Abuse, NIDA, Novel Analgesics, Rice

Category(s): TherapeuticArea > Neurology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics

Cannabinoid Receptor Meditating Compounds for Metabolic Disease

There is evidence that the metabolic effects of endocannabinoids are mediated by CB1 receptors in peripheral tissues. While prior attempts at generating CB1 receptor blockers have had serious neuropsychiatric side effects, inventors at NIH have discovered compounds that block CB1 receptors with reduced brain penetrance. In addition, some of these...

Published: 7/25/2024 | Inventor(s): Malliga Iyer, Resat Cinar, Kenner Rice, George Kunos

Keywords(s): 4, 5-Dihydro-1H-Pyrazole, Derivatives, IB6XXX, IBXXXX, Peripherally, Restricted, VFXXXX, VHXXXX, WKXXXX, YAXXXX

Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Reproductive Health