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A Human Progenitor Mast Cell Line for Allergic and Fibrotic Research and Therapeutic Screening

Hermansky-Pudlak Syndrome type-1 (HPS-1) is a rare genetic disorder that affects around 1 in 500,000 people worldwide and 1 in 1,800 Puerto Ricans. Patients with HPS-1 display oculocutaneous albinism, bleeding due to platelet abnormality, and pulmonary fibrosis. Those that develop pulmonary fibrosis often succumb and live no more than a decade after...

Published: 7/25/2024 | Inventor(s): Dean Metcalfe, Arnold Kirshenbaum

Keywords(s): 16bp, c.1470-1486dup16, Cell, Cells, Cloning, Defect, DUPLICATION, EXPANSION, Expressing, FceRI, Hermansky, HPM, HPS1, Human, Immature, KNOWN, Line, Promastocyte, Pudlak, RECEPTORS, Syndrome-1

Category(s): Collaboration Sought > Collaboration

Hspa2 Knockout Mice for Study of Spermatogenesis and Male Infertility

HSPA2 is a member of the HSP70 family of heat-shock proteins that serve as molecular chaperones. Researchers discovered that HSPA2 protein is expressed in spermatogenesis during the meiotic phase. Spermatogenic cells lacking the HSPA2 protein arrest in mid-meiosis and undergo apoptosis. HSPA2 is present in the synaptonemal complex of wild-type mice...

Published: 7/25/2024 | Inventor(s): Edward Eddy

Keywords(s): Deletion, Gene, Generation, Hsp70-2, Hspa2, IDXXXX, IXXXXX, KNOWN, Mouse, previously, Spermatogenesis, Strain, Targeted

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Therapeutics, Application > Research Materials