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WNT1-Induced Secreted Protein-1 Knockout Mouse Model

WNT1-induced secreted protein-1 (WISP1) is expressed at high levels in osteoblasts and their precursors. WIPS1 plays an important role in various aspects of bone formation. Scientists at the NIH generated Wisp1-deficient (Wisp1-/-) mice. Deletion of Wisp1 resulted in a decrease in bone mineral density, total bone volume, bone thickness, and biomechanical...

Published: 7/25/2024 | Inventor(s): Azusa Maeda, Mitsuaki Ono, Marian Young

Keywords(s): DEFICIENT, Generation, Mice, OSTEOGENESIS, VAXXXX, VPXXXX, WISP1, WIXXXX, XCXXXX, XEXXXX, YCXXXX

Category(s): TherapeuticArea > Ophthalmology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, Application > Research Materials, TherapeuticArea > Geriatrics, Application > Diagnostics